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Tracking cell specific gammaherpesvirus gene expression in vivo: host phenotype vs virus genotype

Reference	S18918
Principal Investigator / Supervisor	Professor Anthony Nash
Co-Investigators / Co-Supervisors	Professor Bernadette Dutia, Dr Jane Rosbottom
Institution	University of Edinburgh
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	358,136
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	31/08/2006
Duration	40 months

Abstract

Herpesviruses have evolved sophisticated strategies to persist within their host. Gammaherpesviruses, such as murine herpesvirus-68 (MHV-68), establish life long latency in lymphocytes. In order to study the cellular basis of virus latency and persistence and the virus genes associated with these processes we plan to exploit cre-lox conditional mutagenesis. We will develop strategies to a) visualise infected cells during the transition from acute to latent infection and select these cells to determine virus gene expression, and b) analyse the effect of cell specific inactivation of virus gene expression on the biology of the infection in vivo. Exploiting cre-recombinase-expressing cells or virus and floxed cellular and viral genes offers a new approach to study virus persistence and pathogenesis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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