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Function of intracellular calcium pools in renal transport: unravelling complexities using targetted calcium reporters

Reference	S18917
Principal Investigator / Supervisor	Professor Shireen Davies
Co-Investigators / Co-Supervisors	Professor Julian Dow, Dr Selim Terhzaz
Institution	University of Glasgow
Department	Molecular Genetics
Funding type	Research
Value (£)	274,768
Status	Completed
Type	Research Grant
Start date	01/06/2003
End date	31/05/2006
Duration	36 months

Abstract

The components of intracellular calcium signalling have been identified largely through work on cell lines and specialised physiological systems, and the time is now ripe to apply an integrative approach. Drosophila is an ideal organism, because of the availability of multiple cell signalling mutants from work on the eye, and because of the targeted aequorin system we have developed. Our recent work on the Malpighian (renal) tubule has suggested that the eye paradigm may not be general, and indeed may be a special case. We will use nuclear, mitochondrial and E.R. targeted aequorin, in addition to our original cytoplasmic aequorin, to dissect the relative contributions, and interactions between, distinct calcium pools in the genetically distinct cell types in tubule.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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