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Long-term modulation of excitability in an identified neurone as a cellular mechanism of long-term associative memory

Reference	S18916
Principal Investigator / Supervisor	Professor George Kemenes
Co-Investigators / Co-Supervisors	Professor Paul Benjamin, Professor Michael O'Shea
Institution	University of Sussex
Department	Biology and Environmental Science
Funding type	Research
Value (£)	281,292
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

It is largely unknown how learning-induced changes in neuronal excitability contribute to long-term memory (LTM) expressed at the systems level. We have recently shown that a persistent increase in the excitability and an underlying sodium current of an identified modulatory neuron of the snail (Lymnaea) feeding system are key components of cAMP and cGMP dependent associative LTM. We want to exploit this discovery to elucidate cAMP and cGMP-dependent mechanisms that lead to persistent modifications in ionic currents involved in the learning-induced excitability increase in the Cerebral Giant Cells (CGCs). Using a combination of cellular and behavioural methods we then want to link our cellular level findings to learning in intact animals.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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