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A transgenic approach to investigating the function of intrinsically photosensitive retinal ganglion cells in mammals
Reference
S18912
Principal Investigator / Supervisor
Professor Robert Lucas
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
182,248
Status
Completed
Type
Research Grant
Start date
01/11/2003
End date
31/03/2007
Duration
41 months
Abstract
In addition to the classical rod and cones that subserve image forming vision recent evidence suggests that a small proportion of retinal ganglion cells (RGCs) can act as photoreceptors in mammals. These RGCs project to retinorecipient areas of the brain that are responsible for driving non-image forming light responses such as circadian entrainment and the pupillary light reflex. We propose examining the role of these RGC photoreceptors in several non-image forming light responses by assessing the effects of a transgenic lesion of these cells. Among the questions this animal will address are i) what proportion of the light information reaching the SCN/OPN/IGL is provided by these RGC photoreceptors ii) what quality of light information do they provide iii) whether they are the only inner retinal photoreceptors in mammals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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