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Technology development: a mouse model of the hamster tau mutation to study integrative circadian physiology
Reference
S18856
Principal Investigator / Supervisor
Professor Andrew Loudon
Co-Investigators /
Co-Supervisors
Professor Raymond Boot-Handford
,
Professor Hugh Piggins
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
314,116
Status
Completed
Type
Research Grant
Start date
17/11/2003
End date
16/11/2006
Duration
36 months
Abstract
Circadian clocks require biochemical regulation of time-delays in transcriptional feedback loops, which confer 24h rhythmicity. Genetic studies reveal casein kinase-1 epsilon (CK1e) as a core component, and a mutation in hamsters of CK1 epsilon impacts on physiology of central and peripheral oscillators. We aim to dissect circadian behaviour by developing both a CK1 epsilon tau mutant and a CK1 epsilon null mutant mouse, and define the impact of these mutations on circadian oscillators regulating behaviour and cyclical gene expression of canonical clock genes. The targeting strategy involves both a null mutation substitutional approach, obviating potential difficulties associated with potential lethality of null CK1 epsilon animals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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