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Elucidation of the genetic basis of a major X-linked QTL influencing murine growth
Reference
S18816
Principal Investigator / Supervisor
Professor Peter Keightley
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
310,148
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
31/08/2006
Duration
41 months
Abstract
We propose to study the genetic basis of murine growth by focusing on a major quantitative trait locus (QTL) we have mapped in previous work to a c.1cM interval of the X chromosome. We propose to identify the causal genetic factor(s) underlying the QTL by ultra-resolution mapping, and to identify all of the candidate alleles by sequencing of the minimal genomic region containing the QTL. We shall characterise the physiological effects of allelic variation at the locus by comparing phenotypes of congenic lines that differ only for the QTL region, correlate changes in expression of candidate gene(s) in the minimal QTL region with changes in phenotype, and investigate the overall effect of variation at the QTL on global gene expression.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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