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Genetic basis for inhibitory co-transmission at a defined neuromuscular junction in C.elegans
Reference
S18811
Principal Investigator / Supervisor
Professor Lindy Holden-Dye
Co-Investigators /
Co-Supervisors
Dr Neil Hopper
,
Professor Vincent O'Connor
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
226,364
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
31/03/2007
Duration
42 months
Abstract
We have identified a neuromuscular junction in the pharynx of C. elegans that involves both inhibitory glutamatergic neurotransmission and an inhibitory neuropeptide FLP13A (APEASPFIRFamide). We will develop an electrophysiological assay, taking advantage of the genetic tractability of C. elegans, to investigate the molecular basis of differential transmitter release mechanisms. In essence we will use this as a way of dissecting the mechanism responsible for differential release of two transmitter types in the physiological setting of an identified neuron. In particular, we will focus on emerging themes which indicate that the organisation of reactions that lie upstream of the final SNARE- dependent fusion can bring about differential release of fast transmitters and classic (FMRF-amide related) neuromodulatory peptides.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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