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Regulation of porcine oocyte maturation
Reference
S18810
Principal Investigator / Supervisor
Professor Martin Luck
Co-Investigators /
Co-Supervisors
Professor Keith Campbell
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
206,924
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
30/06/2006
Duration
39 months
Abstract
We have developed a new technique for the synchronisation of porcine oocytes in vitro which allows their development to be studied in a reliable manner. Such oocytes proceed through the stages of meiosis and achieve MII at the predictable time. This project will exploit the new technique to study the following aspects of porcine oocyte maturation: 1) intracellular kinase activity and interaction during meiosis, 2) the temperature- dependence of maturation over a narrow physiological range, 3) the mechanism by which temperature influences meiosis, 4) the time- dependence and contact-dependence of cumulus-oocyte interactions during meiosis. These studies will improve understanding of oocyte maturation, suggest the most appropriate conditions for laboratory procedures and aid the efficient production of oocytes for research and fertility manipulation.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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