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Protein synthesis and transport at the ageing blood-cerebrospinal fluid barrier
Reference
S18786
Principal Investigator / Supervisor
Dr Jane Preston
Co-Investigators /
Co-Supervisors
Dr Ruo Chen
,
Dr Malcolm Segal
Institution
King's College London
Department
School of Health and Life Sciences
Funding type
Research
Value (£)
289,424
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
01/04/2006
Duration
36 months
Abstract
The cerebrospinal fluid (CSF) plays a key role maintaining brain nutrient homeostasis, delivering hormones and drugs to target sites and removing toxins/waste products. CSF is actively secreted by choroid plexuses (CP) which also synthesise CSF proteins, transthyretin (thyroxine-binding protein), growth factor-binding protein and insulin-like growth factor, all involved in hormone delivery to maintain brain health. With increasing age CSF secretion declines, protein levels alter and both may contribute to brain ageing. This project aims to investigate CP synthesis of these proteins, mRNA expression, CSF transport and protein entry into brain in young and old sheep using both in vitro and in vivo techniques.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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