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Age-related cognitive changes in healthy humans: influences from genetic variation in genes related to oxidative stress
Reference
S18386
Principal Investigator / Supervisor
Professor Ian Deary
Co-Investigators /
Co-Supervisors
Professor John Starr
,
Professor Lawrence Whalley
Institution
University of Edinburgh
Department
Psychology
Funding type
Research
Value (£)
216,812
Status
Completed
Type
Research Grant
Start date
01/03/2003
End date
30/04/2008
Duration
62 months
Abstract
Non-pathological age-related cognitive decline in humans affects quality of life and is a burden to society. There is variation in rates of cognitive change; it is a quantitative trait. Finding sources of this variation is essential to understanding and countering cognitive decline in old age. We hold unique phenotypic data on over 700 people who provided cognitive data at age 11 and at age 80. They also provided much social, physiological and psychological data. DNA samples have been stored from all subjects. The present study uses these data in a collaboration with molecular geneticists. We hypothesise that variation in genes related to oxidative stress and antioxidant defences contribute to variations in cognitive decline.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Ageing, Neuroscience and Behaviour
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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