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The pedunculopontine tegmental nucleus and sustained attention
Reference
S18381
Principal Investigator / Supervisor
Professor Philip Winn
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Psychology
Funding type
Research
Value (£)
369,932
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
30/09/2006
Duration
42 months
Abstract
Experiments will test the hypothesis that the pedunculopontine tegmental nucleus (PPTg) is important in sustained attention. (i) We will compare and contrast deficits in sustained attention after bilateral lesions of PPTg, the laterodorsal tegmental nucleus (which is adjacent to PPTg and closely related to it) and the nucleus basalis of Meynert (known to be involved in sustained attention). Psychopharmacological experiments will determine whether or not cholinergic neurons in all of these structures regulate sustained attention. (ii) We will examine the hypothesis that PPTg gets rapidly analysed sensory data from superior colliculus for relaying to thalamus and striatum. We will adopt a multidisciplinary approach using tracing techniques, measurement of transmitter release, induction of lesions, psychopharmacology and behavioural analyses.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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