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Phosphotransferases in hormonal regulation of development in Drosophila
Reference
S18376
Principal Investigator / Supervisor
Professor Huw Rees
Co-Investigators /
Co-Supervisors
Dr Alan Shirras
,
Dr Philip Turner
Institution
University of Liverpool
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
217,884
Status
Completed
Type
Research Grant
Start date
18/11/2002
End date
18/11/2005
Duration
36 months
Abstract
Ecdysteroids (moulting hormones) regulate development in insects by exhibiting mandatory peaks in titre at specific stages. The ecdysteroid phosphotransferases (kinases), which are unique steroid phosphotransferases, catalyse the formation of various ecdysteroid phosphates and are important in the hormonal inactivation process at the appropriate times. The objective is to characterise in Drosophila, ecdysteroid phosphotransferase genes and to elucidate the functional significance of these enzymes in regulation of development. The functional genomics approaches to be used include data mining, proteomics, in situ hybridisation, and knock-out (or knock-down) techniques.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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