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Functional genomics of homeostatic plasticity in phenotypically-defined hypothalamic neurons
Reference
S18346
Principal Investigator / Supervisor
Professor David Murphy
Co-Investigators /
Co-Supervisors
Dr Julian Paton
Institution
University of Bristol
Department
Physiology and Pharmacology
Funding type
Research
Value (£)
366,472
Status
Completed
Type
Research Grant
Start date
15/02/2003
End date
14/07/2006
Duration
41 months
Abstract
In response to dehydration, the hyporthalamo-neurohypophyseal system (HNS) secretes vasopressin into the circulation. We have used microarrays to describe how the pattern of gene expression in changes in the HNS following dehydration. We hypothesise that differentially expressed genes represent candidate regulators and effectors of HNS physiological plasticity. We will test this using adenoviral gene transfer. We will determine the functional consequences of altered gene activity in terms of integrated cardiovascular control - water balance in the whole organism, hormone release, sympathetic nerve traffic, baroreceptor reflex function and neuronal excitability. This will include the development of a novel reduced in situ preparation for the HNS that will enable the rapid and systematic assessment of the physiological consequences of transgene expression.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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