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How does uncoupling protein-3 affect skeletal muscle phenotype: small but strong?
Reference
S18218
Principal Investigator / Supervisor
Professor Nancy Curtin
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Div of Biomedical Sciences
Funding type
Research
Value (£)
220,680
Status
Completed
Type
Research Grant
Start date
01/09/2003
End date
28/02/2007
Duration
42 months
Abstract
Uncoupling protein-3, mitochondrial transporter believed to waste energy as heat without ATP synthesis. Transgenic mice over- expressing UCP-3 are lean despite being hyperphagic and having a normal level of locomotion. Thus with extra UCP-3, obesity is avoided, but are there disadvantages? We have evidence that the metabolic cost of supplying muscle ATP demand is higher when extra UCP-3 present. Since sustained contractile performance requires a balance of ATP demand and supply, we predict that muscle with extra UCP-3 will perform less well and UCP-3 knock-outs better, than wild type in tests of graded contraction severity. This information is relevant to the usefulness of UCP-3 as a target for obesity-control interventions in humans.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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