Award details

Characterisation of bovine natural killer (NK) cells and their role in determining immune bias

ReferenceS18169
Principal Investigator / Supervisor Professor Jayne Hope
Co-Investigators /
Co-Supervisors
Institution The Pirbright Institute
DepartmentDiv of Immunology Compton
Funding typeResearch
Value (£) 194,972
StatusCompleted
TypeResearch Grant
Start date 01/04/2003
End date 31/08/2006
Duration41 months

Abstract

Mycobacterium bovis causes bovine tuberculosis and can cause potentially fatal infections in humans as well as having a profound economic impact on cattle herds in infected areas. We have identified a putative NK cell in neonatal calves that proliferates and synthesises IFN gamma in response to M. bovis-BCG infected dendritic cells. This interaction may be critical for the generation of protective cellular immune responses that need to have the strong Th1 bias necessary for effective immunity against TB. We propose to characterise NK-like cells present in cattle and determine their role in the induction of Th1 biased immune responses. The requirements for stimulation of the cells will be determined and their immunological functions characterised.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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