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Characterisation of bovine natural killer (NK) cells and their role in determining immune bias
Reference
S18169
Principal Investigator / Supervisor
Professor Jayne Hope
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
194,972
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
31/08/2006
Duration
41 months
Abstract
Mycobacterium bovis causes bovine tuberculosis and can cause potentially fatal infections in humans as well as having a profound economic impact on cattle herds in infected areas. We have identified a putative NK cell in neonatal calves that proliferates and synthesises IFN gamma in response to M. bovis-BCG infected dendritic cells. This interaction may be critical for the generation of protective cellular immune responses that need to have the strong Th1 bias necessary for effective immunity against TB. We propose to characterise NK-like cells present in cattle and determine their role in the induction of Th1 biased immune responses. The requirements for stimulation of the cells will be determined and their immunological functions characterised.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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