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Ontogeny endocrine control and functional significance of leptin and the leptin receptor in fetal sheep during late gestation

ReferenceS18103
Principal Investigator / Supervisor Dr Alison Forhead
Co-Investigators /
Co-Supervisors
Professor Abigail Fowden
Institution University of Cambridge
DepartmentPhysiology Development and Neuroscience
Funding typeResearch
Value (£) 207,184
StatusCompleted
TypeResearch Grant
Start date 28/04/2003
End date 27/10/2006
Duration42 months

Abstract

Leptin is an important regulator of appetite and energy expenditure in adult life, although its physiological role in fetal growth and development is poorly understood. The main aims of this project are to determine (a) the developmental changes in circulating leptin and gene expression of leptin and its receptor in fetal tissues during late gestation, (b) the control of leptin action by hormones, such as cortisol and insulin, and (c) the effect of leptin on linear growth rate and blood hormone and metabolite concentrations in utero.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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