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Identification of candidate protective antigens for vaccination against the bovine lungworm Dictyocaulus viviparus
Reference
S17867
Principal Investigator / Supervisor
Professor Robert Beynon
Co-Investigators /
Co-Supervisors
Institution
University of Liverpool
Department
Veterinary Clinical Science
Funding type
Research
Value (£)
208,372
Status
Completed
Type
Research Grant
Start date
01/03/2003
End date
01/03/2006
Duration
36 months
Abstract
Parasitic bronchitis is a serious disease of cattle caused by Dictyocaulus viviparus. A radiation-attenuated larval vaccine has been used for prevention of this disease, but has several disadvantages: a short shelf life and annual production necessitating sacrifice of donor calves. Recent research has been directed at identification and isolation of components involved in survival of D. vivaparus in the host and examination of their potential as vaccine candidates. The excretory and secretory (ES) products of adult worms are protective in guinea pigs and are therefore a source of candidate antigens. This project takes a unique immunological and proteomic approach to identifying adult ES components that may stimulate protection. We aim to identify candidate protective antigens specifically recognised by immune but not by non-immune animals and characterise these antigens using start-of-the-art proteomics approaches. The cDNA encoding of a sub-set of these proteins will be cloned and expressed for future immunisation and functional studies.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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