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Brain mechanisms that underlie reduced corticotropin releasing hormone neurone stress responses in pregnancy
Reference
S17830
Principal Investigator / Supervisor
Professor John Russell
Co-Investigators /
Co-Supervisors
Dr Alison Douglas
Institution
University of Edinburgh
Department
Biomedical Sciences
Funding type
Research
Value (£)
299,916
Status
Completed
Type
Research Grant
Start date
01/03/2003
End date
01/03/2006
Duration
36 months
Abstract
Brain changes in pregnancy, protecting the fetuses, almost abolish paraventricular nucleus (PVN) CRH neurone responses to chemical mediators transducing immune and metabolic signals that usually strongly increase pituitary-adrenal activity. We hypothesise that this hyporesponsiveness to circulating interleukin-1beta and intrahypothalamic orexin-A is due to CRH neurone inhibition by opioids and GABA-neurosteroid interaction, reducing effectiveness of mediation by noradrenaline and neuropeptideY. We will measure ACTH secretion, rapid mRNA expression changes in situ in PVN CRH, brainstem and hypothalamic stressor processing neurones, and use a cDNA microarray to assess regional expression of mRNAs for enzymes producing neurosteroids.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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