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The role of afferent inputs in the regulation of dendritic neuropeptide release
Reference
S17615
Principal Investigator / Supervisor
Professor Mike Ludwig
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Biomedical Sciences
Funding type
Research
Value (£)
178,088
Status
Completed
Type
Research Grant
Start date
15/02/2003
End date
15/02/2006
Duration
36 months
Abstract
Magnocellular neurones of the hypothalamus regulate their local dendritic and distant axonal terminal release of vasopressin and oxytocin differentially. We will address the hypothesis that release from different compartments of a single neuron reflects activation of different pathways which trigger dendritic versus peripheral secretion to different extents. We will monitor regulation of dendritic peptide release in vivo with concurrent monitoring of action potential activity, by combining microdialysis and or chemosensors with electrophysiology. We will electrically activate selected inputs to study their role in preparing (priming) and stimulating dendritic release compared with secretion from axon terminals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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