Award details

Development of novel porcine tissue culture systems to replace animals for identification of virulence genes in Streptococcus suis

Reference	S17603
Principal Investigator / Supervisor	Dr Josh Slater
Co-Investigators / Co-Supervisors	Professor Duncan Maskell, Professor Andrew Rycroft
Institution	University of Cambridge
Department	Veterinary Medicine
Funding type	Research
Value (£)	217,424
Status	Completed
Type	Research Grant
Start date	13/01/2003
End date	12/04/2006
Duration	39 months

Abstract

This project will develop novel in vitro porcine respiratory cell and organ culture systems for assaying the virulence of pig respiratory pathogens thus reducing the number of pigs required to study respiratory infections. We have considerable expertise in the construction and use of similar systems in other species for studying bacterial and viral pathogenesis. This project will use Streptococcus suis, a major pathogen of pigs and also an important zoonosis causing meningitis in humans, as a model organism. A library of S. suis transposon mutants will be used in primary screens in the in vitro infection models. Mutants attenuated for virulence in these models will be tested in a small number of definitive experiments in pigs which will both validate the in vitro models and also provide new, important information about the molecular basis of pathogenicity of S. suis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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