Award details

Structural and functional characterisation of the rat apelin receptor (APJR) gene

Reference	S17600
Principal Investigator / Supervisor	Professor Stafford Lightman
Co-Investigators / Co-Supervisors	Dr Anne-Marie O'Carroll
Institution	University of Bristol
Department	Henry Wellcome Labs for Neuroscience & E
Funding type	Research
Value (£)	314,836
Status	Completed
Type	Research Grant
Start date	06/05/2002
End date	05/10/2005
Duration	41 months

Abstract

The apelin receptor (APJR) has been linked to the regulation of biological processes such as water balance and stress responses. We have been exploring the role of APJR, and its ligand apelin, in the regulation of hypothalamic supraoptic and paraventricular nucleus function to modify hypothalamo-neurohypophysial system (mHNS) and hypothalamic-pituitary-adrenal (HPA) axis activity. The identification and study of the APJR gene promoter region is central to an understanding of APJR gene regulation and ultimately regulation of mHNS and HPA axis activity. This proposal will integrate Reporter gene-, electrophoretic mobility shift assay-, and mutational analyses to elucidate the molecular mechanism by which the expression of APJR is regulated.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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