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The role of a long term potentiation-like mechanism in the response of bone to short durations of mechanical stimulation

Reference	S17443/2
Principal Investigator / Supervisor	Professor T M Skerry
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Medicine and Biomedical Science
Funding type	Research
Value (£)	107,324
Status	Completed
Type	Research Grant
Start date	10/01/2005
End date	09/06/2007
Duration	29 months

Abstract

Mechanisms underlying perception and responsiveness of bone cells to mechanical events are fundamental to the understanding of all conditions characterised by bone loss. Brief periods of mechanical loading initiate prolonged chains of events, but the mechanisms underlying this response are unknown. We have shown that glutamate mediated intracellular signalling in bone has remarkable similarities to synaptic transmission in the CNS and recently, that the apparatus exists in bone cells that would permit long term potentiation (LTP), a process in the CNS by which long-lasting activity-dependent changes in synaptic efficacy occur in response to a brief chain of stimulatory events. These parallels between the observed responses of bone and the process of LTP led to the hypothesis underlying this proposal: that an LTP-like mechanism in bone accounts for its responses to loading.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S17443 The role of a long term potentiation-like mechanism in the response of bone to short durations of mechanical stimulation

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