Award details

Characterisation of bovine respiratory syncytial virus (BRSV)-specific bovine

Reference	S17430
Principal Investigator / Supervisor	Dr Geraldine Taylor
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	Div of Immunology Compton
Funding type	Research
Value (£)	366,700
Status	Completed
Type	Research Grant
Start date	21/10/2002
End date	21/10/2005
Duration	36 months

Abstract

CD8+ T cells play a major role in the clearance of BRSV, an important respiratory pathogen of young calves that share many of the epidemiological and pathological features of human RSV in infants. This project aims to determine if qualitative or quantitative differences in the BRSV-specific bovine CD8+ T cell response affect the outcome of BRSV infection. In this project, the extent to which bovine MHC class I genotype influences the antigenic specificity of the CD8+ T cells, the role of BSRV proteins on the generation and long-term survival of BRSV-specific memory CD8+ T cells and the contribution of CD8+ T cell memory to susceptibility to reinfection, will be investigated. This information will facilitate the development of strategies for eliciting optimally protective CD8+ T cell responses.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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