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The circadian clock of the metazoan model Caenorhabditis elegans

Reference	S17249
Principal Investigator / Supervisor	Professor Charalambos Kyriacou
Co-Investigators / Co-Supervisors	Professor Mark Blaxter, Mr Fred Kippert
Institution	University of Leicester
Department	Genetics
Funding type	Research
Value (£)	320,532
Status	Completed
Type	Research Grant
Start date	20/05/2002
End date	19/11/2004
Duration	30 months

Abstract

We have recently described a circadian clock in Caenorhabditis elegans and identified its first 'clock gene'. With C. elegans as a leading metazoan model for functional genomics, the molecular dissection of its circadian clock can take new avenues of investigation. The proposed project will 1) provide a general characterisation of the circadian clock as basis for any future work, 2) produce and optimise luciferase reporter constructs for high throughput analysis of the clock, 3) identify genes required for the clock by screening about 200 candidate 'clock genes' using dsRNA interference, 4) provide initial insights into causal relationships between the identified genes and the clock process, in collaboration with the C. elegans community.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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