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Oocyte-somatic cell interactions: identification of novel oocyte secreted proteins
Reference
S17232
Principal Investigator / Supervisor
Professor Morag Hunter
Co-Investigators /
Co-Supervisors
Professor Robert Webb
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
305,596
Status
Completed
Type
Research Grant
Start date
01/07/2002
End date
28/02/2006
Duration
44 months
Abstract
It is becoming clear that follicular development is dependent upon and:or influenced by the oocyte. However, the mechanisms through which the oocyte exerts its effects are ill defined. We will investigate the influence of known oocyte secreted factors on somatic cell function in vitro and define the temporal expression of other likely candidates in somatic-germ cell interactions (e.g. GDF-9, BMP-15). The ovarian autotransplant gilt model will be exploited to obtain numbers of synchronised early follicles. We will then use proteomics to identify specific proteins secreted by, or expressed in oocytes at defined stages of development. Novel oocyte proteins secreted in a temporal manner that are likely to be key regulators of follicle growth will be identified, sequenced and biological activity assessed.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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