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Significance of divergent expression patterns of inhibin-A and inhibin-B during ovarian follicle development in hens

ReferenceS17120
Principal Investigator / Supervisor Professor Philip Knight
Co-Investigators /
Co-Supervisors
Dr Richard Gladwell, Dr Tristan Lovell
Institution University of Reading
DepartmentAnimal and Microbial Sciences
Funding typeResearch
Value (£) 157,624
StatusCompleted
TypeResearch Grant
Start date 14/04/2002
End date 14/04/2004
Duration24 months

Abstract

We recently discovered a striking divergence in expression patterns of inhibin-A (inhA) and inhibin-B (inhB) during follicle development in the hen; inhA peaks in the largest preovulatory follicle (F1) while inhB peaks in much smaller (7-9mm) follicles that are about to enter preovulatory hierarchy. Given the recent identification of 2 candidate inhibin co- receptors in mammals (inhBP and beta-glycan) that may be selective for inhB and inhA respectively, we propose to (i) identify and clone the chicken homologues of these 2 receptors (ii) compare the temporal and spatial expression patterns of inhBP, beta-glycan, inhB and inhA during follicle development in vivo, during the ovulatory cycle in vivo and in isolated theca and granulosa cells in vitro. These studies will yield novel data and help elucidate the roles of different inhibin isoforms in avian folliculogenesis.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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