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Role of thyrotropin - releasing hormone (TRH) in the hypothalamic control of energy balance in a seasonal animal model

Reference	S17106
Principal Investigator / Supervisor	Professor Fran Ebling
Co-Investigators / Co-Supervisors	Dr Geoffrey Bennett, Dr Sandrine Schuhler
Institution	University of Nottingham
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	289,952
Status	Completed
Type	Research Grant
Start date	01/08/2002
End date	31/10/2006
Duration	51 months

Abstract

The aim of this project is to understand the role of thyrotrophin-releasing hormone (TRH) in the control of food intake and body weight. The actions of this neuropeptide in regulating metabolism via the pituitary-thyroid axis are well known, but our pilot studies indicate that it also has actions within the hypothalamus which also influence energy metabolism. Our studies exploit seasonal cycles in obesity in Siberian hamsters. We will determine whether long-term reduction in appetite and loss of body weight in winter reflects increased activity of TRH within the hypothalamus. This will be accomplished by measuring feeding behaviour, related physiological responses and TRH function in the seasonally obese and lean states after manipulation of the TRH system.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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