BBSRC Portfolio Analyser
Award details
Paramyxoviruses interferons and virus:host cell protein:protein interactions
Reference
S17016
Principal Investigator / Supervisor
Professor Richard Randall
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
227,540
Status
Completed
Type
Research Grant
Start date
01/01/2003
End date
01/01/2006
Duration
36 months
Abstract
A common mechanism employed by paramyxoviruses to circumvent the interferon (IFN) response is to block IFN signalling. SV5 and hPIV2 target STAT1 and STAT2, respectively, for proteasome-mediated degradation, and cell-lines lacking either STAT1 or STAT2 were simply isolated by expressing the appropriate V protein. Proteomics will be used to i) identify the host cell proteins that interact with V, ii) determine how expression of V changes cellular protein expression and iii) ascertain whether cells lacking either STAT1 or STAT2 can respond to either IFNa:b or IFNg. The mechanism(s) by which IFNs inhibit paramyxovirus replication will also be examined. The knowledge gained from such studies may lead to improved vaccines and novel drugs.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search