Award details

Potential novel role for a neuropeptide signalling system in the circadian clock

Reference	S16862
Principal Investigator / Supervisor	Professor Hugh Piggins
Co-Investigators / Co-Supervisors	Professor Anthony Harmar, Professor Andrew Loudon, Professor Alexej Verkhratsky
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	352,116
Status	Completed
Type	Research Grant
Start date	12/12/2001
End date	29/04/2005
Duration	41 months

Abstract

The master circadian clock located in the suprachiasmatic nuclei (SCN) is synchronised by daily exposure to light. Recently, we implicated vasoactive intestinal polypeptide (VIP) and its VPAC2 receptor in mediating these photic effects on the clock. Remarkably, targeted deletion of the VPAC2 receptor stops the mouse SCN clock, indicating that VIP signalling pathways may also be important for sustaining central clock activity. In this proposal, we will establish the role of VIP and the VPAC2 receptor in regulating the circadian effects of light and in the maintenance of circadian rhythmicity and clock output, from the level of clock gene expression through to behaviour and neuroendocrine rhythms. (Joint with grant 26/S16863).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S16863 Potential novel role for a neuropeptide signalling system in the circadian clock

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