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Towards an understanding of malignant catarrhal fever at the molecular level

Reference	S16844
Principal Investigator / Supervisor	Professor James Stewart
Co-Investigators / Co-Supervisors
Institution	University of Liverpool
Department	Medical Microbiology & GenitoUrinary Med
Funding type	Research
Value (£)	253,592
Status	Completed
Type	Research Grant
Start date	01/07/2002
End date	01/07/2005
Duration	36 months

Abstract

Malignant fever is a fatal lymphoproliferative disorder of domestic cows, pigs and deer. It is caused by a group of related gammaherpesviruses that persist in a latent form in a carrier species (e.g. sheep). The central feature of this disease is the emergence of promiscuously cytotoxic T cells that carry virus. Currently little is known about how these viruses cause disease. In this project we propose to study the pathogenesis of one of these viruses, alcelaphine herpesvirus type 1 (AlHV-1). We aim to study AlHV-1 gene expression in infected T cells and then study the function of expressed genes and their contribution to the cytotoxic phenotype and disease in model systems. The results will enhance our knowledge of the fundamental disease processes and may also have implications for the development of control and vaccination strategies for malignant catarrhal fever.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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