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Towards an understanding of malignant catarrhal fever at the molecular level

Principal Investigator / Supervisor Professor James Stewart
Co-Investigators /
Institution University of Liverpool
DepartmentMedical Microbiology & GenitoUrinary Med
Funding typeResearch
Value (£) 253,592
TypeResearch Grant
Start date 01/07/2002
End date 01/07/2005
Duration36 months


Malignant fever is a fatal lymphoproliferative disorder of domestic cows, pigs and deer. It is caused by a group of related gammaherpesviruses that persist in a latent form in a carrier species (e.g. sheep). The central feature of this disease is the emergence of promiscuously cytotoxic T cells that carry virus. Currently little is known about how these viruses cause disease. In this project we propose to study the pathogenesis of one of these viruses, alcelaphine herpesvirus type 1 (AlHV-1). We aim to study AlHV-1 gene expression in infected T cells and then study the function of expressed genes and their contribution to the cytotoxic phenotype and disease in model systems. The results will enhance our knowledge of the fundamental disease processes and may also have implications for the development of control and vaccination strategies for malignant catarrhal fever.


Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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