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Tick salivary gland fatty acid binding proteins

Reference	S16728
Principal Investigator / Supervisor	Dr Alan Bowman
Co-Investigators / Co-Supervisors
Institution	University of Aberdeen
Department	Inst of Biological and Environmental Sci
Funding type	Research
Value (£)	191,660
Status	Completed
Type	Research Grant
Start date	01/04/2002
End date	31/05/2005
Duration	38 months

Abstract

An intracellular fatty acid binding protein (SG-FABP) isolated from the salivary glands of the lone star tick (Amblyomma americanum) is postulated to play an important role in arachidonic acid and eicosaniod metabolism. The project proposes to characterise SG-FABP by: 1) sequencing the SG-FABP cDNA and producing a functional recombinant SG-FABP; 2) assessing the binding properties of SG-FABP regarding its range of ligands, including prostaglandins and arachidonic acid; 3) assessing the developmental expression and in vitro induction of SG-FABP and immunolocalization of SG-FABP to the salivary gland cell type and intracellular compartmentalisation.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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