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Molecular and cellular analysis of a novel murine model of virus-induced fibrosis
Reference
S16644
Principal Investigator / Supervisor
Professor Anthony Nash
Co-Investigators /
Co-Supervisors
Professor Bernadette Dutia
,
Dr Bahram Ebrahimi
Institution
University of Edinburgh
Department
Veterinary Pathology
Funding type
Research
Value (£)
230,536
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
01/04/2005
Duration
36 months
Abstract
Previous work supported by the BBSRC has led to the establishment of a murine model of virus-induced fibrosis. This condition is triggered by infection of interferon-g receptor negative mice with murine gammaherpesvirus and affects the lymphoid system, lung and liver. Remarkably the fibrosis resolves and the affected tissues regain normal function. We propose to analyse the cellular and molecular mechanisms underpinning this condition using microarray technology and molecular pathology techniques. We will also map the virus genes at the left end of the genome associated with the induction (and resolution?) of fibrosis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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