Award details

Regulation of luteinisation and progesterone secretion in the bovine corpus luteum

Reference	S16622
Principal Investigator / Supervisor	Professor Morag Hunter
Co-Investigators / Co-Supervisors	Dr George Mann
Institution	University of Nottingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	299,248
Status	Completed
Type	Research Grant
Start date	01/05/2002
End date	01/05/2005
Duration	36 months

Abstract

Inadequate luteal function is a major contributor to infertility in a number of species. This project will use the dairy cow, in which inadequate progesterone secretion during early pregnancy is a major cause of embryo loss, as a model system in which to investigate the endocrine and cellular control of luteinisation and progesterone secretion. We will test the hypothesis that attenuated gonadotrophin secretion causes inadequate follicular maturation, which leads to decreased expression of angiogenic factors (VEGF, bFGF), steroidogenic enzymes (P450scc, 3beta-HSD) and LH receptor in the resulting corpus luteum. We will then supplement gonadotrophin secretion to manipulate key regulators of luteal development and optimise luteal function.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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