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Metabotropic glutamate recptors supralinear Ca2+ signalling and associative synaptic plasticity in the hippocampus
Reference
S16613
Principal Investigator / Supervisor
Dr Andrew Irving
Co-Investigators /
Co-Supervisors
Professor Bruno Frenguelli
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
261,492
Status
Completed
Type
Research Grant
Start date
01/08/2002
End date
01/08/2005
Duration
36 months
Abstract
Metabotropic glutamate (mGlu) receptors can act as novel associativity sensors through the generation of supralinear Ca2+ signals. The current proposal will use advanced confocal imaging techniques and electrophysiology to characterise further mGlu receptor-mediated supralinear Ca2+ signalling in the hippocampus, from the level of Ca2+ rises expressed within dendritic spines to global Ca2+ signals observed throughout the entire neuron. We will focus on the role of Ca2+ stores and Ca2+-induced Ca2+ release during coincident activation of mGlu receptors and activity-dependent Ca2+ influx pathways. Functional studies will relate these processes to associative synaptic plasticity and recency detection.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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