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Involvement of monoamines in spinal analgesic actions of opioids
Reference
S16591
Principal Investigator / Supervisor
Dr John Harris
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
181,732
Status
Completed
Type
Research Grant
Start date
22/04/2002
End date
21/06/2005
Duration
38 months
Abstract
Opioids are analgesic because they inhibit nociceptive transmission in the spinal cord. Work from this laboratory has shown that inhibition of spinal reflexes by fentanyl (a) depends on endogenous noradrenaline, and (b) is partially mediated by brain stem serotonergic neurones. This project will investigate:- (i) the extent to which these opioid- monoamine interactions apply to sensory transmission neurones in spinal cord; (ii) how the monoamine involvement in opioid function may be altered in conditions of inflammation and nerve damage; and (iii) if other opioids interact with monoamines in the manner demonstrated for fentanyl. The data obtained will aid in the design of analgesic strategies for long-term pain states.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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