Award details

The role of peroxisome proliferator-activated receptor axis in the developmental fate of brown adipocyte precursor cells

Reference	S16040
Principal Investigator / Supervisor	Professor Michael Lomax
Co-Investigators / Co-Supervisors	Professor David Hazelrigg
Institution	University of Aberdeen
Department	Agriculture and Forestry
Funding type	Research
Value (£)	229,028
Status	Completed
Type	Research Grant
Start date	18/02/2002
End date	17/05/2003
Duration	15 months

Abstract

Non-shivering thermogenesis depends on expression of the uncoupling protein, UCP1, in brown adipose tissue (BAT). This is essential for preventing ruminant neonatal hypothermia, and its effects on energy balance may have implications for human obesity. In sheep, we have shown that there is an irreversible developmental loss of UCP1 after birth. This project aims to identify the molecular mechanisms responsible for the ontogenic programming of adipocyte function. We hypothesise that developmental control of BAT depends upon changes in the function of the peroxisome proliferator-activated receptor (PPAR) axis. We will establish the ontogenesis of PPAR axis gene expression in adipose tissue in vivo and in primary adipocyte cultures. Further in vitro experiments will examine how interactions between the PPAR axis and other regulatory inputs determine UCP1 inducibility.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/X/00050 The role of the peroxisome proliferator-activated receptor axis in the developmental fate of the brown adipocyte precursor cells

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