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Intestinal DNA immunisation; the role of dendritic cells in determining optimal responses

Reference	S15885
Principal Investigator / Supervisor	Dr Gordon MacPherson
Co-Investigators / Co-Supervisors	Professor Linda Klavinskis
Institution	University of Oxford
Department	Sir William Dunn Sch of Pathology
Funding type	Research
Value (£)	321,568
Status	Completed
Type	Research Grant
Start date	15/07/2002
End date	14/03/2006
Duration	44 months

Abstract

Oral DNA vaccines have huge potential in controlling intestinal infection but stimulate weak intestinal immunity, probably because intestinal cells are refractory to bacterial CpG DNA. Dendritic cells (DC) play a central role in immunity, carrying antigen and regulating T cell activation and differentiation. Controlling DC properties may be the key to effective immunisation. To investigate this we will immunise rats with DNA containing antigen and cytokine genes, assess cellular and humoral responses, analyse gene expression in enterocytes, using our unique model to analyse DC migrating from intestine to nodes, and determine if such DC can transfer immunity to naive rats. This project will improve intestinal DNA vaccination

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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