BBSRC Portfolio Analyser
Award details
Spike timing-dependent synaptic plasticity during network oscillations in the hippocampus in vitro
Reference
S15862
Principal Investigator / Supervisor
Professor Ole Paulsen
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Physiology Anatomy and Genetics
Funding type
Research
Value (£)
250,100
Status
Completed
Type
Research Grant
Start date
10/01/2002
End date
09/04/2005
Duration
39 months
Abstract
Synaptic plasticity is widely believed to contribute to information storage in the brain. Correlated pre- and postsynaptic activity can induce synaptic changes, but the precise plasticity rules remain unclear. During acquisition of memory in behaving animals, networks in the brain display rhythmic oscillations at several distinct frequencies. The aim of this project is to investigate whether such network oscillations can provide the temporal structure necessary to induce spike correlation-dependent synaptic modifications and which rules apply for induction of these changes. This will be investigated by patch-clamp recording from pairs of synaptically connected neurons during cholinergically- induced oscillations in rodent hippocampal slices.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search