Award details

Fine mapping of a quantitative trait locus with a major influence on murine growth

Reference	S15858
Principal Investigator / Supervisor	Professor Peter Keightley
Co-Investigators / Co-Supervisors	Dr Julian Christians
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	104,156
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/02/2004
Duration	28 months

Abstract

This project will study the genetic basis of growth in mice, focusing on a quantitative trait locus (QTL) identified in previous work. We propose to refine the position of this QTL and to examine candidate genes in the region. Genotyping of existing samples at additional markers, followed by progeny testing of congenic lines that differ for a segment of chromosome 1 containing the QTL, will refine its position of approximately 0.25cM. Such resolution will facilitate the identification of a small number of candidate genes using data from the mouse and human genome sequences. Analysis of expression and sequence variation in these genes will further refine the list of candidates, paving the way for the underlying gene(s) to be cloned.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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