BBSRC Portfolio Analyser
Award details
The role of a calcineurin mediated pathway in skeletal muscle mechano-transduction
Reference
S15855
Principal Investigator / Supervisor
Dr Paul Loughna
Co-Investigators /
Co-Supervisors
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
188,804
Status
Completed
Type
Research Grant
Start date
01/05/2002
End date
01/05/2005
Duration
36 months
Abstract
Mechanical stimuli are powerful anabolic signals in skeletal muscle and can also produce specific changes in gene expression. The mechanisms by which mechanical signals are transduced into altered growth and qualitative changes in gene expression are unknown. This project will examine whether the Ca2+ calmodulin- dependent protein phosphatase calcineurin plays a crucial role in this process. The role of calcineurin in mediating stretch-induced hypertrophy and altered patterns of gene expression will be examined in vivo in muscles of different phenotypes and in vitro in the C2C12 cell line. Stretch induces muscle cells to secrete IGF- 1. The paracrine role of IGF-1 in contributing to the upregulation of calcineurin pathways will also be examined.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search