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Hormonal and cellular regulation of glucocorticoid metabolism in the bovine ovary
Reference
S15850
Principal Investigator / Supervisor
Dr Dilkush Abayasekara
Co-Investigators /
Co-Supervisors
Dr Anthony Michael
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
192,960
Status
Completed
Type
Research Grant
Start date
01/12/2001
End date
31/07/2005
Duration
44 months
Abstract
In the ovary, glucocorticoids are rendered inactive by the enzyme 11beta-hydroxysteroid dehydrogenase (11betaHSD). Low 11betaHSD activities have been correlated with the establishment of pregnancy in human IVF patients. This study proposes to investigate how hormonal modulators of ovarian function control the expression and activity of 11betaHSD isoforms (11betaHSD1 and 11betaHSD2) in (a) the developing ovarian follicle and (b) the corpus luteum of the cow. The results of this research will advance our understanding of the cellular mechanisms by which the response of ovarian cells to adrenal steroids are controlled, and may indicate how this enzyme system could be manipulated to improve bovine fertility.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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