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Award details
Identification and characterisation of chicken toll-like receptors
Reference
S15839
Principal Investigator / Supervisor
Dr Adrian Smith
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Molecular Biology Pirbright
Funding type
Research
Value (£)
190,976
Status
Completed
Type
Research Grant
Start date
14/08/2002
End date
14/08/2005
Duration
36 months
Abstract
Mammalian toll-like receptors (TLRs) are known to play an important role in the induction of the innate and adaptive immune responses and are associated with susceptibility to infectious disease. We aim to isolate chicken TLRs and to determine whether they are associated with genetic resistance to common poultry diseases using the IAH panel of inbred chicken lines which are known to differ in their resistance/susceptibility to a wide range of pathogens. Further, we will examine the role of TLRs in the chicken immune response by characterising the expression patterns of relevant tissues and cells before and after infectious challenge and by developing models to examine the specificity and function of individual TLR family members.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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