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Analysis of Gene 5 of the avian coronavirus infectious bronchitis virus utilising a reverse genetics system

Reference	S15836
Principal Investigator / Supervisor	Professor David Cavanagh
Co-Investigators / Co-Supervisors	Professor Paul Britton, Dr Rosa Casais
Institution	The Pirbright Institute
Department	Div of Molecular Biology
Funding type	Research
Value (£)	174,308
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/10/2004
Duration	36 months

Abstract

Coronaviruses contain, in addition to four structural protein and replicase genes, several additional, often polycistronic, genes whose products are presumed to be non-structural. Currently the function of these genes is unknown for any coronavirus. We propose to use our newly developed reverse genetics system for the avian coronavirus IBV to determine whether Gene 5, which encodes two ORFs, is (1) essential for replication; and (2) whether removal of one or other ORF affects virulence. IBV Gene 5 has no counterpart in any other coronavirus but is present in all IBVs isolated to date and in IBV-like viruses isolated from species other than chickens. The adjacent intergenic region, the only one in IBV, will also be studied in this context.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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