BBSRC Portfolio Analyser
Award details
Functional significance of insulin-like growth factor binding proteins-5(IGFBP-5)
Reference
S15716
Principal Investigator / Supervisor
Dr Jennifer Pell
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Developmental Genetics and Imprinting
Funding type
Research
Value (£)
178,660
Status
Completed
Type
Research Grant
Start date
11/02/2002
End date
10/02/2005
Duration
36 months
Abstract
IGFBP-5 overexpressing mice are severely growth retarded (40-50 percent) pre- and postnatally, skeletal muscle mass being the most acutely decreased. We will examine the hypothesis that IGFBP-5 has functional significance during growth and development by characterising key mechanisms in IGFBP-5 action. Three possibilities exist: i) IGFBP-5 has only IGF-modulating effects, ii) IGFBP-5 has IGF-independent actions due to specific functional motifs (nuclear localisation, phosphorylation), iii) co- operation between both these properties confers gain-of- function to the IGFs. Endogenous IGFBP-5 is specifically upregulated during myoblast differentiation; therefore myogenesis is an excellent physiological model for IGFBP- 5 action. Integrated in vivo (transgenic) and in vitro (myoblast culture) approaches will be combined with IGFBP-5 site-directed mutagenesis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search