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The acute phase protein response in an experimental model of Staphylococcus aureus mastitis in dairy cows

Reference	S15699
Principal Investigator / Supervisor	Professor Peter Eckersall
Co-Investigators / Co-Supervisors	Dr J Beeley, Professor Julie Fitzpatrick, Professor Andrea Nolan
Institution	University of Glasgow
Department	Veterinary School
Funding type	Research
Value (£)	169,192
Status	Completed
Type	Research Grant
Start date	01/02/2002
End date	01/02/2004
Duration	24 months

Abstract

Mastitis affects severely the health and welfare of dairy cows and reduces the quantity and quality of milk. This research team has established that the acute phase proteins (APP), haptoglobin (Hp) and serum amyloid A (SAA) are present in quarters of dairy cows with mastitis and could be valuable markers in detection of mastitis. Preliminary results suggest that SAA, but not Hp, is synthesised locally during intramammary infection. The project will extend these findings in an in vivo experimental model of Staphylococcus aureus-induced mastitis and by in vitro mammosphere culture. The pathophysiology of APP induced in milk and in particular, its time course and tissue and cellular location, will be determined. Proteomic investigation will identify further protein or peptide changes in milk related to the onset and progress of mastitis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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