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Characterisation of human ovarian gonadotrophin surge-attenuating factor (GnSAF/IF)

Reference	S15655
Principal Investigator / Supervisor	Professor Paul Fowler
Co-Investigators / Co-Supervisors	Dr William Harrison, Professor Helen Mason, Ms Tarja Sorsa
Institution	University of Aberdeen
Department	Department of Obstetrics & Gynaecology
Funding type	Research
Value (£)	69,495
Status	Completed
Type	Research Grant
Start date	01/09/2001
End date	01/09/2002
Duration	12 months

Abstract

Phage display antibodies have been developed which recognise GnSAF/IF bioactivity and also clones in a human ovary cDNA library. The single chain antibodies have been converted to human IgGs and will be used to: 1). identify the specific GnSAF/IF protein by immunopurification, Western blot and bioactivity monitoring of 2D gels of granulosa cell-conditioned medium; 2). Characterise the GnSAF/IF protein and gene sequence; and 3). Develop a GnSAF/IF immunoassay using immunopurified or recombinant GnSAF/IF. This project will finally resolve one of the reproductive enigmas of the last 20 years and will provide the basis for the assessment of the importance and potential of GnSAF/IF in both medical and veterinary situations.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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