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Dogfish cytokine genes: cloning production of recombinant molecules and bioactivity
Reference
S15536
Principal Investigator / Supervisor
Professor Chris Secombes
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
Inst of Biological and Environmental Sci
Funding type
Research
Value (£)
168,676
Status
Completed
Type
Research Grant
Start date
01/02/2002
End date
01/02/2005
Duration
36 months
Abstract
Following our recent breakthrough in the cloning of the first cartilaginous fish cytokine gene, for interleukin- 1beta in the dogfish, this programme proposes to isolate two more dogfish cytokine genes using a homology cloning approach and to study 1) where the genes are expressed in an organism with many unique lymphoid tissues, 2) what impact the recombinant cytokines have on the activity of dogfish phagocytes and antibacterial defences, 3) how the expression of these genes is regulated during infection and stress, and 4) whether the gene promoters show any unique features.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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