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Gene expression profiles of CD4+T cells during chronic intestinal helminth infection

Reference	S15449
Principal Investigator / Supervisor	Professor Kathryn Else
Co-Investigators / Co-Supervisors	Professor Andy Brass
Institution	The University of Manchester
Department	Computer Science
Funding type	Research
Value (£)	231,412
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/11/2004
Duration	37 months

Abstract

Intestinal nematodes are some of the most prevalent infections of domestic animals. Infections tend to be chronic with often high reinfection rates and cause substantial economic loss worldwide. To develop effective disease control by immunotherapeutic means we need to understand the immune events associated with the maintenance of chronicity. Most of our understanding of immunity to parasitic infection comes from studies in the laboratory mouse. Trichuris muris in the mouse provides a unique model system for analysing the mechanisms underlying prolonged infection. We propose to characterise the gene expression profiles of CD4+ T cells during chronic intestinal helminth infection using high throughput transcriptome analysis. This powerful approach has the potential to reveal unique insights into the transcriptional events that underlie chronicity.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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