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Identification of macrophage expressed genes involved in resistance to an infectious pathogen
Reference
S15354
Principal Investigator / Supervisor
Professor Elizabeth Glass
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
Genetics and Genomics
Funding type
Research
Value (£)
224,196
Status
Completed
Type
Research Grant
Start date
03/09/2001
End date
03/09/2004
Duration
36 months
Abstract
Macrophage expressed genes involved in host responses to infectious disease will be identified. This project builds on earlier studies that identified significant differences in resistance to a protozoan parasite between Bos indicus (Sahiwal) and B. taurus (Friesan cattle). The extensive pathology induced in Friesians and immunity induced in Sahiwals appear to be macrophage dependent. A cDNA library and microarray will be created from an mRNA pool of resting, activated and infected bovine macrophages. Global gene expression changes in activated and infected macrophages derived from the disease resistant and susceptible breeds of cattle will be compared using microarray analysis. The project will provide new insights into the mechanisms of host-pathogen interactions and potentially identify candidate genes determining host disease resistance.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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