Award details

Genetic recombination of traits for protective immunity and drug-resistance in the protozoan Eimeria maxima from the fowl

Reference	S15343
Principal Investigator / Supervisor	Professor Martin Shirley
Co-Investigators / Co-Supervisors	Dr Adrian Smith
Institution	The Pirbright Institute
Department	Div of Molecular Biology Pirbright
Funding type	Research
Value (£)	150,384
Status	Completed
Type	Research Grant
Start date	22/10/2001
End date	22/10/2003
Duration	24 months

Abstract

This is the first part of a novel strategy to identify the few immunoprotective molecules from an antigenically complex intracellular protozoan pathogen. A genetic cross will be established between two strains of Eimeria maxima that induce complete protection to homologous challenge but no protection to heterologous challenge in the infected host. Demonstration that strain-specific protective immunity can recombine independently with a drug-resistance marker will allow a new integrative genetic mapping and immunological approach in which loci encoding protective antigens will be mapped in recombinant parasites that derive from the genetic cross. This approach is unique and directly identifies protective antigen- encoding loci.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search